I have used the mx-editor with Windows Vista a few times and it has worked fine. I did have it crash once but I'm not sure if it was from Vista or something else at that time. Anyway yes it will work.

I do have some software that is not working with Vista so it can be an issue with some things. Currently my email program "Incredimail" and my Cannon scanner will not work with Vista. BTW Vista is pretty nice :)