Yes.

First, you can easily bind a button or menu option to send one or many infrared commands. So you can easily recreate what you have currently.

However, where the Harmony excels is its internal state. Basically you can tell it to remember whether the TV is in Anamorphic or Normal mode. So you can get it to work out whether it needs to press the "Anamorphic Toggle" button when you finish watching a DVD and go back to normal TV.

This is handy for avoiding phone calls from the other half ... "Why can't I watch TV - you've broken it" etc!