It's very unlikely that any universals will have built in codes to work a PC. If your RS remote is a learning remote (eg, a 15-1994, 15-2116, 15-2117, etc) then you could get the optional IR remote, learn the signals and then use JP1 to create an upgrade to work it.
If the program you wish to control is "Windows Media Center" then you're in luck, because there's already an upgrade available in the JP1 group, so you wouldn't even need to get the optional remote.
Rob
http://www.hifi-remote.com