Slack,
Here are the Replay units in Harmony's list of "known" devices:
ReplayTV 2000 (PVR)
ReplayTV 4000 (PVR)
ReplayTV PV-HS2000 (PVR)
ReplayTV Replay 4080 (PVR)
ReplayTV RTV-3030 (PVR)
ReplayTV RTV-3060 (PVR)
You can always learn from your original remote and modify the listings as you'd like them as well. I do have to say that the Harmony is a little more of a chore to use with a PVR due to the lack of buttons, and does require some computer time to get it properly set up.
Bruce-
You can use the Replay with both your cable and satellite. You won't be able to do anything with the HD channels, but that's a different output from your satellite box anyway.
Mike
www.surfremotecontrol.com