I haven't done a 6000 yet. On any other URC remote, however, I have found that for multiple zones it is best to give each room a separate watch/listen page with activities laid out similarly for each room. Also, if you have devices like a cable box that are common to each room, you must create a separate device for the common component for each room so that your volume and power off buttons are using the appropriate codes for that particular room's TV volume or AV receiver.

Yes, you will have to tell the remote what room you are in each time you power up - page over to the appropriate room (page) in Watch/ Listen, that is unless you are good with logic statements/nested macros. I need to learn how to do this! Hope this helps.