It's one thing to have a remote be tied to a given room, most remotes will do this with no problem.

But are all your sources distributed? Or are some of the sources in a central location, all of them, or a split. This makes a difference because how you'd use functions like "Watch" or "Listen" will be dramatically affected by trying to reconfigure the remote to think it's in a different room. I'm not sure a text screen remote would be up to the task (without being obscenely tedious to use). If you want roaming remotes you're really going to want to consider the MX-3000.

The Pronto's are out of the running for lack of variables. Yeah, you could configure an endless array of pages to counter all situations but, ugh, that's way too much work. And if Harmony stick with using their web-based setup for the 1000 (to be shipped...) you'd have a real challenge getting it setup.

What you may find, however, is a mix of remotes works best. Some simple stick-type remotes, possibly even without a display at all, that are tied to each room. This gives you a good "toss around" remote that'll stand up to daily use. Then have a couple of MX-3000 units configured to "do it all".

But programming a remote for that complex a setup is not for the novice. yeah, you could just slog your way through it but there's any number of gotchas that can only be avoided by having done a lot of programming before.