Well, the Prontos are much, much higher-end than Harmonies. Both remotes will fully control your devices.

If you want touchscreens, go with a Pronto.

Another option is URC's MX-850. It's a great remote-much more customizable that the Harmony, 20 devices, huge code database, fully learning, macros, and pretty easy to program, although not as easy as the Harmony. It also has 5 pages dedicated to Favorite Channels, with 10 channels per page, so there's spots for 50 channels.