Nevermind, I just got off the phone with Philips and the NEO will not work with a USB - Serial adapter cable. Luckily I have another IBM Thikpad with a serial port otherwise the remote would be going back. I however was a little frustrated that Philips didn't touch on this anywhere/anyhow. Their new remotes TSU3000 and another one are USB compatable as per the tech that I talked to.