Have you tried a "hard reset"? I believe there is a tiny button inside the battery compartment that resets the remote. I don't know if you have to push it once or hold it for the hard reset and I don't have the manual. Either way, it will clear whatever is on the remote and revert to the default setting. Then I would make sure you have the latest software version of neo edit. Also make sure you have the latest firmware version for the remote. Update them both and then try to download your configuration.

For your serial-usb problem do a search on the forum....I recall seeing other users who had to use a certain brand of usb adapter to get it to work.