I stated with a blank slate, as I deleted everything out of the default.ncf save for one function that I needed. My system consist of the RCR Utv, RCA rear projection Tv, and the Sony 200 DVD changer.
I have over 48 Favorite channels and 180 DVD's all set up with macros plus a few others and I have around 30 learned ir codes as the rest were in the datebase that came with the Neo. All the macros use links as this takes less memory as the IR code is then only used once.
On the Neo remote it says 100% memory free under the last page of the setup screen...
So if this is showing me an accurate reading, Id say you would be hard pressed to use up all the memory! Even the Pronto ts1000 with 1meg of ram I believe rarely runs out, and with the NEo you can't have bitmaps on the main device screen and the bitmapes you do have are smaller, so I'd say that it would be the least to worry about.