Do you mean multiple remotes or multiple computers? It must be remotes, because I am only talking about one computer....

It fails on all ccfs that I open and try to emulate. Without even a remote. I'm one of these guys who never learns into the software, and I have not seen much advantage to using a mouse on an emulator to actually emit IR, so when I use the emulator, it is just to see what the panel changes look like. That is how I have always used it in all versions of the software. I had this problem one time before with Touch Screen Setup, and reinstallation fixed it.